Post by This Just In on Apr 17, 2020 7:57:46 GMT -5
The Trail Leading Back to the Wuhan Labs
Below are excerpts from the article:
The Wuhan Institute of Virology in China indeed posted a job opening on November 18, 2019, “asking for scientists to come research the relationship between the coronavirus and bats.”
The Google translation of the job posting is: “Taking bats as the research object, I will answer the molecular mechanism that can coexist with Ebola and SARS- associated coronavirus for a long time without disease, and its relationship with flight and longevity. Virology, immunology, cell biology, and multiple omics are used to compare the differences between humans and other mammals.” (“Omics” is a term for a subfield within biology, such as genomics or glycomics.)
On December 24, 2019, the Wuhan Institute of Virology posted a second job posting. The translation of that posting includes the declaration, “long-term research on the pathogenic biology of bats carrying important viruses has confirmed the origin of bats of major new human and livestock infectious diseases such as SARS and SADS, and a large number of new bat and rodent new viruses have been discovered and identified.”
In his YouTube video, Matthew Tye focuses his attention on a researcher at the Wuhan Institute of Virology named Huang Yanling: “Most people believe her to be patient zero, and most people believe she is dead.”
The web page for the Wuhan Institute of Virology’s Lab of Diagnostic Microbiology does indeed still have “Huang Yanling” listed as a 2012 graduate student, and her picture and biography appear to have been recently removed — as have those of two other graduate students from 2013, Wang Mengyue and Wei Cuihua.
Tye says, “everyone on the Chinese internet is searching for [Huang Yanling] but most believe that her body was quickly cremated and the people working at the crematorium were perhaps infected as they were not given any information about the virus.” (The U.S. Centers for Disease Control and Prevention says that handling the body of someone who has died of coronavirus is safe — including embalming and cremation — as long as the standard safety protocols for handing a decedent are used. It’s anyone’s guess as to whether those safety protocols were sufficiently used in China before the outbreak’s scope was known.)
That Radio France Internationale report on February 17 also mentioned the next key part of the Tye’s YouTube video. “Xiaobo Tao, a scholar from South China University of Technology, recently published a report that researchers at Wuhan Virus Laboratory were splashed with bat blood and urine, and then quarantined for 14 days.” HK01, another Hong Kong-based news site, reported the same claim.
This doctor’s name is spelled in English as both “Xiaobo Tao” and “Botao Xiao.” From 2011 to 2013, Botao Xiao was a postdoctoral research fellow at Harvard Medical School and Boston Children’s Hospital, and his biography is still on the web site of the South China University of Technology.
At some point in February, Botao Xiao posted a research paper onto ResearchGate.net, “The Possible Origins of 2019-nCoV coronavirus.” He is listed as one author, along with Lei Xiao from Tian You Hospital, which is affiliated with the Wuhan University of Science and Technology. The paper was removed a short time after it was posted, but archived images of its pages can be found here and here.
The first conclusion of Botao Xiao’s paper is that the bats suspected of carrying the virus are extremely unlikely to be found naturally in the city, and despite the stories of “bat soup,” they conclude that bats were not sold at the market and were unlikely to be deliberately ingested.
The bats carrying CoV ZC45 were originally found in Yunnan or Zhejiang province, both of which were more than 900 kilometers away from the seafood market. Bats were normally found to live in caves and trees. But the seafood market is in a densely-populated district of Wuhan, a metropolitan [area] of ~15 million people. The probability was very low for the bats to fly to the market. According to municipal reports and the testimonies of 31 residents and 28 visitors, the bat was never a food source in the city, and no bat was traded in the market.
The U.S. Centers for Disease Control and Prevention and the World Health Organization could not confirm if bats were present at the market. Botao Xiao’s paper theorizes that the coronavirus originated from bats being used for research at either one of two research laboratories in Wuhan.
We screened the area around the seafood market and identified two laboratories conducting research on bat coronavirus. Within ~ 280 meters from the market, there was the Wuhan Center for Disease Control & Prevention. WHCDC hosted animals in laboratories for research purpose, one of which was specialized in pathogens collection and identification. In one of their studies, 155 bats including Rhinolophus affinis were captured in Hubei province, and other 450 bats were captured in Zhejiang province. The expert in Collection was noted in the Author Contributions (JHT). Moreover, he was broadcasted for collecting viruses on nation-wide newspapers and websites in 2017 and 2019. He described that he was once by attacked by bats and the blood of a bat shot on his skin. He knew the extreme danger of the infection so he quarantined himself for 14 days. In another accident, he quarantined himself again because bats peed on him.
Surgery was performed on the caged animals and the tissue samples were collected for DNA and RNA extraction and sequencing. The tissue samples and contaminated trashes were source of pathogens. They were only ~280 meters from the seafood market. The WHCDC was also adjacent to the Union Hospital (Figure 1, bottom) where the first group of doctors were infected during this epidemic. It is plausible that the virus leaked around and some of them contaminated the initial patients in this epidemic, though solid proofs are needed in future study.
The second laboratory was ~12 kilometers from the seafood market and belonged to Wuhan Institute of Virology, Chinese Academy of Sciences . . .
In summary, somebody was entangled with the evolution of 2019-nCoV coronavirus. In addition to origins of natural recombination and intermediate host, the killer coronavirus probably originated from a laboratory in Wuhan. Safety level may need to be reinforced in high risk biohazardous laboratories. Regulations may be taken to relocate these laboratories far away from city center and other densely populated places.
Below are excerpts from the article:
The Wuhan Institute of Virology in China indeed posted a job opening on November 18, 2019, “asking for scientists to come research the relationship between the coronavirus and bats.”
The Google translation of the job posting is: “Taking bats as the research object, I will answer the molecular mechanism that can coexist with Ebola and SARS- associated coronavirus for a long time without disease, and its relationship with flight and longevity. Virology, immunology, cell biology, and multiple omics are used to compare the differences between humans and other mammals.” (“Omics” is a term for a subfield within biology, such as genomics or glycomics.)
On December 24, 2019, the Wuhan Institute of Virology posted a second job posting. The translation of that posting includes the declaration, “long-term research on the pathogenic biology of bats carrying important viruses has confirmed the origin of bats of major new human and livestock infectious diseases such as SARS and SADS, and a large number of new bat and rodent new viruses have been discovered and identified.”
In his YouTube video, Matthew Tye focuses his attention on a researcher at the Wuhan Institute of Virology named Huang Yanling: “Most people believe her to be patient zero, and most people believe she is dead.”
The web page for the Wuhan Institute of Virology’s Lab of Diagnostic Microbiology does indeed still have “Huang Yanling” listed as a 2012 graduate student, and her picture and biography appear to have been recently removed — as have those of two other graduate students from 2013, Wang Mengyue and Wei Cuihua.
Tye says, “everyone on the Chinese internet is searching for [Huang Yanling] but most believe that her body was quickly cremated and the people working at the crematorium were perhaps infected as they were not given any information about the virus.” (The U.S. Centers for Disease Control and Prevention says that handling the body of someone who has died of coronavirus is safe — including embalming and cremation — as long as the standard safety protocols for handing a decedent are used. It’s anyone’s guess as to whether those safety protocols were sufficiently used in China before the outbreak’s scope was known.)
That Radio France Internationale report on February 17 also mentioned the next key part of the Tye’s YouTube video. “Xiaobo Tao, a scholar from South China University of Technology, recently published a report that researchers at Wuhan Virus Laboratory were splashed with bat blood and urine, and then quarantined for 14 days.” HK01, another Hong Kong-based news site, reported the same claim.
This doctor’s name is spelled in English as both “Xiaobo Tao” and “Botao Xiao.” From 2011 to 2013, Botao Xiao was a postdoctoral research fellow at Harvard Medical School and Boston Children’s Hospital, and his biography is still on the web site of the South China University of Technology.
At some point in February, Botao Xiao posted a research paper onto ResearchGate.net, “The Possible Origins of 2019-nCoV coronavirus.” He is listed as one author, along with Lei Xiao from Tian You Hospital, which is affiliated with the Wuhan University of Science and Technology. The paper was removed a short time after it was posted, but archived images of its pages can be found here and here.
The first conclusion of Botao Xiao’s paper is that the bats suspected of carrying the virus are extremely unlikely to be found naturally in the city, and despite the stories of “bat soup,” they conclude that bats were not sold at the market and were unlikely to be deliberately ingested.
The bats carrying CoV ZC45 were originally found in Yunnan or Zhejiang province, both of which were more than 900 kilometers away from the seafood market. Bats were normally found to live in caves and trees. But the seafood market is in a densely-populated district of Wuhan, a metropolitan [area] of ~15 million people. The probability was very low for the bats to fly to the market. According to municipal reports and the testimonies of 31 residents and 28 visitors, the bat was never a food source in the city, and no bat was traded in the market.
The U.S. Centers for Disease Control and Prevention and the World Health Organization could not confirm if bats were present at the market. Botao Xiao’s paper theorizes that the coronavirus originated from bats being used for research at either one of two research laboratories in Wuhan.
We screened the area around the seafood market and identified two laboratories conducting research on bat coronavirus. Within ~ 280 meters from the market, there was the Wuhan Center for Disease Control & Prevention. WHCDC hosted animals in laboratories for research purpose, one of which was specialized in pathogens collection and identification. In one of their studies, 155 bats including Rhinolophus affinis were captured in Hubei province, and other 450 bats were captured in Zhejiang province. The expert in Collection was noted in the Author Contributions (JHT). Moreover, he was broadcasted for collecting viruses on nation-wide newspapers and websites in 2017 and 2019. He described that he was once by attacked by bats and the blood of a bat shot on his skin. He knew the extreme danger of the infection so he quarantined himself for 14 days. In another accident, he quarantined himself again because bats peed on him.
Surgery was performed on the caged animals and the tissue samples were collected for DNA and RNA extraction and sequencing. The tissue samples and contaminated trashes were source of pathogens. They were only ~280 meters from the seafood market. The WHCDC was also adjacent to the Union Hospital (Figure 1, bottom) where the first group of doctors were infected during this epidemic. It is plausible that the virus leaked around and some of them contaminated the initial patients in this epidemic, though solid proofs are needed in future study.
The second laboratory was ~12 kilometers from the seafood market and belonged to Wuhan Institute of Virology, Chinese Academy of Sciences . . .
In summary, somebody was entangled with the evolution of 2019-nCoV coronavirus. In addition to origins of natural recombination and intermediate host, the killer coronavirus probably originated from a laboratory in Wuhan. Safety level may need to be reinforced in high risk biohazardous laboratories. Regulations may be taken to relocate these laboratories far away from city center and other densely populated places.